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DOLUTEGRAVIR TARGETS THE HYPOTHALAMUS TO SUPPRESS
ENERGY EXPENDITURE VIA ESTROGEN RECEPTOR
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CROI 2024 March 3-6 Denver
Ikrak Jung1, Sunghee Jin1, Woo-Sub Yang3, Yoon-Mi Cho3, Becky Tu-Sekine1, Frederick Anokye-Danso1, In-Hyun Park3, Todd T. Brown1, and Sangwon F. Kim1,2
1Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, 2Solomon H Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA, 3Department of Genetics, Yale University, New Haven, CT, USA
DTG disrupts energy expenditure. In other words, the body becomes a bit inefficient in burning calories while taking DTG.
This is an extension of my previous study showing that DTG reduces energy expenditure by disrupting (brown) adipose tissues, whose primary function is to burn fat. This process is highly regulated by the central nervous system, too. This study shows that DTG can disrupt the signaling in the brain region, which controls energy balance and leads to less energy expenditure.
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