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HIV Transcription Persists in the Brain of People With HIV and Viral Suppression
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(ABSTRACT 113)
CROI 2024
Melissa J. Churchill
RMIT University, Melbourne, Australia
CROI webcast:
https://www.croiwebcasts.org/console/player/52071?mediaType=slideVideo&
"HIV reservoirs exist in the CNS, are transciptionally active & may have the ability to reactivate and/or contribute to neuropathology"
"HIV reservoirs are present at similar levels in the brain of PWH on and off ART"
"Persistent transition occurs in the CNS despite viral suppression"
"HIV is detected in virally suppressed PWH"
"multiple studies have now demonstrated the presence of intact & defective proviral genomes in the CNS of
PWH who are virally suppressed"
"virus isolated from CNS myeloid cells isolated from RT-suppressed PWH following rapid autopsy replication competent ex vivo" (Tang et al JCI 2023)
"amyloid cells identified as major reservoir"
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