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Detailed modelling of viremia exposure does not independently predict cardiovascular disease in people with HIV
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AIDS 2024 July 20-24 Munich
This presentation drew a lot of comments & questions during Q&A. Several comments questioned if the study was able to capture the reported outcome - for one, did they have even PWH with over 1000 HIV viral load in the study to have the power to detect the outcome; another concern raised was that the study could not capture the amount of time a PWH had detectable and high level viremia before diagnosis, which the presenter admitted was a concern - but in the end the presenter felt his results hold up despite the questions raised. Dr Elvstam the presenter agreed this could be an issue. Several commenters raised the point that several studies have been reported at conferences over the past few years finding low level viremia is associated with increased CVD risk and of course the presenters response is in this study they adjusted for other risk factors. Again, several commenters raised questions about belief that this outcome is true. A concern I have is most study participants had high CD4s and this may have compensated in some way in the analysis with the effect of viral load on CVD events. Jules
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