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5'Leader Defects in HIV Plasma Clones Drive 80% of Persistent Viremia on Long-Term ART (NSV)
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Julia R. Box1, Filippo Dragoni1, Angelica Camilo-Contreras1, Feng Yun Yue2, Vitaliy Matveev2, Eileen Scully1, Joyce L. Jones1, Mario Ostrowski2, Colin M. Kovacs2, Francesco R. Simonetti1
1The Johns Hopkins University School of Medicine, Baltimore, MD, USA, 2University of Toronto, Toronto, Canada.
In the context of HIV, "clonal expansion" refers to the proliferation of HIV-infected cells that share the same integrated viral DNA sequence, contributing to the persistence of the latent HIV reservoir and potentially hindering eradication efforts. AI
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