1. I might be starting on a therapy of pegintron (1,5 mcg per kilo) and ribavirine. However, I have heard it is advisable to start with normal IFN first, because of the halftime and side-effects. In that case, how many weeks should I be taking the normal IFN?
 
2. Do you know of any trials comparing the doses of 1,5 and 2 and 3 mcg per kilo pegintron, are there any (preliminary) findings yet?
 
3. Would you recommend a 24 or a 48 week treatment?: I am hcv/hiv positive, but am likely to respond well to treatment because of hcv type 2b and hcv rna of 108000.

In general we have had very little trouble getting pts started on the PEGINTRON + ribavirin. So I do not generally start with the regular IFN. You should be treated for 48 weeks.