I have been on peg combo treatment for 12 weeks. My viral load went from 1 million to 79,000. My Dr was hoping for better. I read that if u don't clear the virus in the first 12 weeks you probably won't have a sustained response. your opinion? Also I found a website that describes the profile for non-responders. 1. over 45 2. Genotyoe 1 3. had HVC over 5 years 4. high viral load 5. Liver scarring I fit the first 3 and 4 if u consider 1 million high viral load. I am stage 2. I don't want stay on this TX if I don't fit the profile to respond your opinion.

Probably true, although the 12 week rule was developed for PEGasys combo, not PEGINTRON combo. those criteria for nonresponders are not hard and fast. if you are genotype 1 and are having a bumpy time with therapy, you may wish to consider stopping early, and waiting for better and better tolerated therapies down the road.