I was in the original clinical trials with interferon (3MU TIW) and ribavirin (1200mg) for one year. I had problems with peripheral neuropathy from the beginning but was told to persevere as they would go away when Istopped treatment. I finished treatment in September 1998 (relapsed) and the neuropathy gradually worsened. I have just been diagnosed with Small Fiber Polyneuropathy. The neurologist is currently investigatiing the ribavirin as the source of the problem but I also see that hepatitis C may be involved. IS HCV INVOLVED? Have you come across this before?
 
Any help would be greatly appreciated.
 
Thank you.
Darlene Morrow

I would try to exclude the diagnosis of cryoglobulinemia, which is not only HCV-associated, but can certainly cause neuropathy. if this test is negative, it may be worth considering the effects of the treatment.