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New Treatment for HIV Lymphoma: Stem-Cell Transplants
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This report contains newspaper article, the text of the study report in Blood and a Commentary in Blood.
"...Notably, in the current era, despite the use of HAART, lymphoma remains a major cause of morbidity and mortality in HIV-infected individuals
...In this issue of the journal Blood, Krishnan and colleagues reported the results of the longest follow-up performed in HIV patients with lymphomas who underwent ASCT (stem-cell transplant). In this series of 20 patients, 17 are still alive and in remission after a median period of observation of 31.8 months. The progression-free survival is 85% and the overall survival (OS) is 85% for the entire group. These results are very impressive and the best reported in literature, but they are affected by a favorable patient selection: 4 patients were in first complete remission (CR). Moreover, the study is not an intention-to-treat analysis as reported by Re et al.3 Therefore, the paper does not completely clarify how many patients with HIV-related lymphomas may really benefit from ASCT..."
...The authors also demonstrated that the underlying HIV infection did not worsen as a result of the transplantation, and CD4 count returned to baseline within 1 year...
... Our long-term follow-up confirms that ASCT can provide durable remissions and can be a potentially curative option for those with otherwise dismal prognosis with conventional therapy..."
"New Hope for HIV Patients"
Pasadena Star-News
(01.18.05)
Kimm Groshong A stem-cell transplant procedure could be a viable treatment option for select HIV-positive patients with relapsed lymphoma, according to new research by City of Hope Cancer Center scientists. In the study, Dr. Amrita Krishnan and colleagues monitored the effects of stem-cell transplants in a group of 20 patients who had both HIV and relapsed lymphoma. Researchers harvested stem cells from the patients, all of whom had previously undergone chemotherapy, gone into remission and then had a relapse of their lymphoma. The patients underwent high-dose chemotherapy for the lymphoma. The stem cells were next re-infused into the patients to produce bone marrow to replace that wiped out by the chemotherapy. Seventeen of the 20 patients (85 percent) are alive and in remission and their HIV infections did not worsen with treatment, said Krishnan. Follow up ranged from six months to six years. Though the transplant procedure is already the standard for HIV-negative patients with relapsed lymphoma, it was widely thought that the potential for infection with treatment was too great in HIV-positive patients and the chances of extracting enough healthy stem cells was too low. Krishnan said this new study refutes that idea. She added that all study patients had well-controlled HIV infections, and their tumors were already in remission for some time following chemotherapy. Three study patients died during treatment or shortly after transplant. More than half the patients were unable to continue taking their antiretroviral HIV therapy during the study due to nausea and mouth inflammation. The research "sets the platform for future trials using stem-cell therapies in HIV-positive patients," said Krishnan. For example, she said, researchers may be able to modify the harvested stem cells to make them HIV-resistant before safely re-infusing them. The full study, "Durable Remissions with Autologous Stem Cell Transplantation for High-Risk HIV-Associated Lymphomas," was published in the journal Blood (2005;105(2):874-878).
Comment on Krishnan et al
"Autologous stem cell transplantation for HIV-infected individuals with relapsed lymphomas: no longer an experimental strategy"
Cecilia Simonelli, and Mariagrazia Michieli
NATIONAL CANCER INSTITUTE, AVIANO, ITALY
High-dose chemotherapy and autologous stem cell transplantation in HIV-infected patients with relapsed lymphomas led to a durable remission with an 85% progression-free survival.
The introduction of highly active antiretroviral therapy (HAART) has reduced the morbidity and mortality of HIV/AIDS with malignancies being the first cause of death. However, HIV-positive patients with relapsed lymphomas have very limited therapeutic options. Autologous stem cell transplantation (ASCT) is the first-choice treatment for HIV-negative patients with relapsed chemosensitive lymphomas. American and European groups, such as ours, have recently explored this approach in HIV patients, and it has been demonstrated that the treatment is feasible and active also in this setting. Previous studies have already shown that it is usually possible to mobilize a sufficient number of stem cells, that HAART can be administrated with high-dose chemotherapy (HDC), and that the rates of infectious complications are similar to the ones occurring in HIV-negative patients when the appropriate prophylaxes are used.1-3
But, up to now, we have little information about the long-term follow-up in these patients, and little is known about the dynamics of immune reconstitution and HIV replication after the ASCT.
In this issue of Blood, Krishnan and colleagues reported the results of the longest follow-up performed in HIV patients with lymphomas who underwent ASCT. In this series of 20 patients, 17 are still alive and in remission after a median period of observation of 31.8 months. The progression-free survival is 85% and the overall survival (OS) is 85% for the entire group (Figure 1). These results are very impressive and the best reported in literature, but they are affected by a favorable patient selection: 4 patients were in first complete remission (CR). Moreover, the study is not an intention-to-treat analysis as reported by Re et al.3 Therefore, the paper does not completely clarify how many patients with HIV-related lymphomas may really benefit from ASCT.
The authors also demonstrated that the underlying HIV infection did not worsen as a result of the transplantation, and CD4 count returned to baseline within 1 year. This observation is not a surprise; in fact, we have observed that HIV patients with relapsed lymphomas treated with HDC and ASCT with the same program offered to the general population had the same dynamics of immune reconstitution.4 In the Krishnan et al series, the long-term follow-up showed that 10 of 17 patients experienced viral failure and needed HAART changes, nevertheless the CD4 count overcame the baseline level at the second year. All of these observations demonstrated that the iatrogenic immunodepression following ASCT not only does not significantly differ from HIV-negative patients, but it might not enhance HIV progression, if particular attention is taken in the management of HAART and antiretroviral options are still available.
This paper not only confirms the feasibility and the favorable long-term survival of ASCT in HIV patients, but clearly points out that this therapeutic strategy should be offered as a salvage therapy in HIV-related relapsed chemosensitive lymphomas, while it should be considered still experimental for patients in first CR. {blacksquare}
Reference
1. Gabarre J, Marcelin AG, Azar N, et al. High-dose therapy plus autologous hematopoietic stem cell transplantation for human immunodeficiency virus (HIV)-related lymphoma: results and impact on HIV disease. Haematologica. 2004;89: 1100-1108.[Medline]
2. Molina A, Krishnan A, Nademanee A, et al. High-dose therapy and autologous stem cell transplantation for the human immunodeficiency virus-associated non-Hodgkin's lymphoma in the era of highly active antiretroviral therapy. Cancer. 2000;89: 680-689.[CrossRef][Medline]
3. Re A, Cattaneo C, Michieli M, et al. High dose therapy and autologous peripheral blood stem cell transplantation as salvage treatment for HIV-associated lymphomas in patients receiving highly active antiretroviral therapy. J Clin Oncol. 2003;23: 4423-
4. Simonelli C, Michieli M, Spina M, et al. Immunereconstitution after high dose chemotherapy (HDC) and peripheral blood stem cell transplantation (PBSCT) in HIV+ patients (pts) vs HIV- pts [abstract]. 8th International Conference on Malignancies in AIDS and Other Immunodeficiencies. April 2004. Abstract 10. Bethesda, MD.
Blood, 15 January 2005, Vol. 105, No. 2, pp. 874-878.
TRANSPLANTATION
"Durable remissions with autologous stem cell transplantation for high-risk HIV-associated lymphomas"
Amrita Krishnan, Arturo Molina, John Zaia, David Smith, Debbie Vasquez, Neil Kogut, Peter M. Falk, Joseph Rosenthal, Joseph Alvarnas, and Stephen J. Forman
From the City of Hope Hematologic Neoplasia Program, City of Hope Cancer Center, Division of Hematology and Hematopoietic Stem Cell Transplantation, Duarte, CA.
ABSTRACT: The treatment of HIV-associated lymphoma has changed since the widespread use of highly active antiretroviral therapy. HIV-infected individuals can tolerate more intensive chemotherapy, as they have better hematologic reserves and fewer infections. This has led to higher response rates in patients with HIV-associated Hodgkin disease (HD) or non-Hodgkin lymphoma (NHL) treated with chemotherapy in conjunction with antiretroviral therapy. However, for patients with refractory or relapsed disease, salvage chemotherapy still offers little chance of long-term survival. In the non-HIV setting, patients with relapsed Hodgkin disease (HD) or non-Hodgkin lymphoma (NHL) have a better chance of long-term remission with high-dose chemotherapy with autologous stem cell rescue (ASCT) compared with conventional salvage chemotherapy. In a prior report we demonstrated that this approach is well tolerated in patients with underlying immunodeficiency from HIV infection. Furthermore, similar engraftment to the non-HIV setting and low infectious risks have been observed. Herein, we expand upon this early experience with the largest single institution series of 20 patients. With long-term follow-up we demonstrate that ASCT can lead to an 85% progression-free survival, which suggests that this approach may be potentially curative in select patients with relapsed HIV-associated HD or NHL.
AUTHOR DISCUSSION
ASCT has become an accepted standard of care for patients with relapsed aggressive NHL and certain patients with relapsed HD. The mortality of this procedure has declined to the point that we are now performing transplants in older patients as well as in patients with other comorbid illnesses. However, this has not become a standard of care with HIV lymphoma, despite significant advances in the treatment of HIV infection. Patients are living longer and suffering from fewer opportunistic infections.
Notably, in the current era, despite the use of HAART, lymphoma remains a major cause of morbidity and mortality in HIV-infected individuals.17,18 While the use of concomitant chemotherapy and HAART has increased remission rates and improved survival, options for patients with refractory or relapsed lymphoma are limited.19,20 Results even in the HAART era with salvage therapy have been poor. For example, in a group of 13 patients with refractory or relapsed HIV-NHL, 7 of whom were on protease inhibitor--based therapy, all treated with ESHAP (etoposide, cisplatinum, cytarabine, solumedrol), median survival was only 7.1 months.19 An even shorter median survival in the pre-HAART era was reported from an Italian group who treated 21 patients with HIV-NHL either refractory to primary chemotherapy or in first relapse. Of the 19 evaluable patients, 5 achieved a CR (26%), and median survival in the CR patients was 13 months, but for the entire cohort median survival was only 2.1 months.20 Thus, for these high-risk patients, better treatment options are clearly needed.
Prior to the advent of HAART, HIV infection was considered a contraindication to both solid organ and stem cell transplantation. Certainly this was borne out by the early allogeneic transplant experience in HIV-infected patients, which was characterized by high rates of opportunistic infections.21,22 However, as our understanding of how to administer antimicrobial prophylaxis in conjunction with antiretroviral therapy has improved, centers have revisited the issues of transplantation in patients with HIV lymphoma.
One of the early series of ASCT was from France. Gabarrre et al used both radiation and chemotherapy-based conditioning regimens for a group of patients with HIV HD and NHL.14 They included multiply relapsed patients as well as primary refractory patients. Infectious complications were similar to our series, with opportunistic infections including CMV viremia noted. Of the 14, 6 (43%) were alive at the time of reporting, with the longest follow-up being 31 months. Another series, a multi-institutional trial from Italy, was performed using a standard chemotherapy-based conditioning regimen of BEAM (carmustine, cytarabine, etoposide, melphalan).13 They too included refractory as well as relapsed patients. The patients received debulking chemotherapy prior to ASCT, although details of disease status at the time of ASCT were not provided. Sixteen patients were enrolled in the trial and analyzed on an intent-to-treat basis. Fifteen patients underwent stem cell collection. Three patients failed to mobilize adequate stem cells for ASCT. Of the remaining 12, 2 had disease progression before ASCT, one did not proceed to ASCT, and one did and subsequently died of progressive disease 4 months after ASCT. Ten other patients went on to ASCT, of which 9 were evaluable at the time of reporting. Median follow-up is short (8 months), but 8 patients achieved a CR or PR after ASCT. Median disease-free survival and overall survival of the cohort undergoing ASCT was 11 months and 18 months, respectively. Projected 2-year overall survival for the entire group is 39%.
The most recent series reported from Spain included many first CR patients.15 However, their definition of first CR also included patients who required more than one line of chemotherapy to achieve a CR, as well as Burkitt-type lymphoma patients who were initially undertreated and then achieved CR with other therapy. All patients but one were in CR at the time of ASCT. The majority received BEAM as the conditioning regimen; median follow-up was 21 months (range, 1-28). Disease-free survival was 73%. Infectious complications were similar to all other series and included one case of herpes zoster and one case of pulmonary aspergillus.
The reported experiences mirror some of the challenges in treating these patients, for example, difficulty in stem cell mobilization. Based on the same experience in 2 patients, our antiretroviral regimens were modified. Specifically, patients cannot be on an antiretroviral regimen containing zidovudine before or after ASCT nor on trimethroprim sulfamethoxazole for pneumocystis prophylaxis before stem cell collection. After transplant, all groups report similar infectious complications, such as herpes zoster. This too has led to a modification in our post-ASCT care in that all patients after discharge are now maintained on oral acyclovir for at least 1 year.
The varied results reported in these series may in part reflect patient selection. For example, the inclusion of chemotherapy refractory patients in the French series, as well as patients with multiple relapses, may have been a factor in the lower disease-free survival in this study. Similarly, the Italian series analyzed all patients with HIV lymphoma who were considered for transplant. Not surprisingly, they demonstrated a markedly better survival in the patients who went on to ASCT, moreover, the median survival of this subgroup is similar to the other series. Our experience is unique in that it is a single institution experience and provides the longest follow-up. Patient selection may have played a bias in our good results in that most patients had to demonstrate chemotherapy-sensitive disease, but we too included multiply relapsed patients as well as those patients not in CR after first-line chemotherapy. Moreover, our transplant selection criteria in regards to the underlying lymphoma are no different than that in our HIV-negative lymphoma patients. In fact, we consider the HIV infection to be akin to a chronic illness that can be managed with appropriate prophylaxis and surveillance. However, we do require that eligible patients must have well-controlled HIV infection as manifested by low HIV viral loads to optimize the chance of stem cell mobilization and minimize infectious risks. The other series do not include this criteria, although the Italian series did require a CD4 count of more than 100/mcl and an effective HAART regimen. Hence, one can postulate that in part, the superior disease-free survival in our series is mediated by well-controlled HIV infection. Certainly in the nontransplant setting, studies have demonstrated that the use of HAART is an independent prognostic factor for event-free survival in HIV NHL.23,24 The experience of all the centers suggests that ASCT should be considered earlier after demonstration of chemotherapy sensitivity for those in first relapse or with primary refractory disease, as the procedure can be performed with low procedural-related mortality. Further research is needed for those with high-risk first CR. Our long-term follow-up confirms that ASCT can provide durable remissions and can be a potentially curative option for those with otherwise dismal prognosis with conventional therapy.
INTRODUCTION
The incidence of Hodgkin disease (HD) and non-Hodgkin lymphoma (NHL) in HIV-infected individuals is much greater than in the HIV-negative population.1,2 In earlier decades the treatment of lymphoma in the setting of immune deficiency was far less successful than in the HIV-negative patient.3 This was in part due to the poor hematologic reserves of HIV-infected patients but was also due to higher rates of infection and higher rates of relapse of the lymphoma. The advent of highly active antiretroviral therapy (HAART) altered the natural history of HIV infection by reducing the incidence of opportunistic infections and improving the underlying immune deficiency.4 In addition, combining HAART with chemotherapy or consolidating chemotherapy with HAART has increased remission rates in both HIV-associated Hodgkin and non-Hodgkin lymphoma.5,6 Recent studies also have confirmed that the International Prognostic Index (IPI) is applicable to patients treated with HAART and chemotherapy.7 For HIV-infected lymphoma patients with high-risk features as defined by the IPI, relapse rates are still high after conventional chemotherapy. Furthermore, for HIV-infected patients with either relapsed HD or NHL the current salvage chemotherapy regimens offer little chance of long-term survival.
In the HIV-negative setting, studies have shown that high-dose therapy with autologous stem cell transplant (ASCT) is the optimal therapy for relapsed HD and NHL.8-10 As the procedure-related mortality of ASCT has decreased, ongoing studies are exploring its use in high-risk first remission patients.10 Now that HIV-infected individuals have markedly improved immune and hematologic function, the use of both solid organ and ASCT is being explored in patients with underlying immunodeficiency and concomitant malignancy or organ dysfunction.11-15 Herein we report the City of Hope Comprehensive Cancer Center experience on the largest single institution series of patients with HIV-associated lymphomas undergoing ASCT. Our initial experience demonstrated the feasibility of this approach in terms of stem cell mobilization, engraftment, and low regimen-related toxicity.16 Now with long-term follow-up in a larger series of patients we demonstrate that ASCT can provide durable remissions in a subset of these high-risk patients.
Patients
HIV-positive patients with NHL who failed to achieve complete remission (CR) after standard-dose front-line chemotherapy or had a chemosensitive relapse (partial relapse [PR] or CR) after an initial CR were eligible. HIV NHL patients with high-risk disease in first CR as defined by the IPI also were eligible. Patients with HD with a chemotherapy-sensitive relapse were eligible. All pathology was reviewed at the City of Hope by a hematopathologist. Inclusion criteria were the institutional standard criteria for ASCT-cardiac ejection fraction higher than 50% by either MUGA (gated resting cardiac-wall motion study) scan or echocardiogram, 24-hour urine creatinine clearance more than 60 ccs per minute, diffusion capacity more than 50% predicted, liver function tests less than 2 x normal, less than 10% bone marrow involvement with lymphoma, and no central nervous system (CNS) involvement with lymphoma. Patients with prior positive cerebrospinal fluid (CSF) cytology were eligible if the CSF cleared with intrathecal therapy. Positive hepatitis serology was not an exclusion criterion but required further evaluation, including a liver biopsy. Initially, the first 5 patients were required to have an absolute CD4 count of more than 100 mcl at the time of lymphoma diagnosis or recurrence. However, this requirement was deleted for subsequent patients. All patients had to have an HIV viral load of less than 10 000 cp/mL by reverse transcriptase--polymerase chain reaction (RT-PCR) at enrollment. Patients had to be free of opportunistic infections for one year prior to enrollment, except for treatment for responsive thrush, mycobacterium, and herpes infections. All patients had to be receiving highly active antiretroviral therapy (HAART). The City of Hope's Institutional Review Board approved the protocol, and informed consent was obtained from each patient in accordance with institutional guidelines.
Treatment
Patients in first remission had peripheral blood stem cells (PBSCs) collected upon recovery from standard front-line chemotherapy or after cyclophosphamide (2 g/m2) plus granulocyte colony-stimulating factor (G-CSF) (10 µg/kg) for stem cell priming. Patients in partial remission (PR) or with relapsed disease received a variety of salvage chemotherapy regimens. Those who demonstrated chemotherapy response had PBSCs collected upon recovery from another cycle of the same chemotherapy. Details of stem cell collection have been outlined previously.16 In order to avoid myelosuppression, patients on trimethoprim sulfamethoxazole were changed to inhaled pentamidine for pneumocystis prophylaxis prior to stem cell collection. A minimum of 5 x 106 CD34+ cells/kg was collected. The first 5 patients had additional stem cells collected for use in gene therapy trials.
Two high-dose therapy regimens were used. A chemotherapy-based regimen of carmustine 150 mg/m2/daily (day -5 to -7), etoposide 60 mg/kg adjusted to body weight (day -4), cyclophosphamide 100 mg/kg ideal body weight (day -2), or a radiation-based regimen of fractionated total body irradiation (FTBI) to a total dose of 1200 cGy, etoposide 60 mg/kg (day -4), cyclophosphamide 100 mg/kg ideal body weight (day -2). Patients younger than 55 years of age with bulky disease or extranodal disease who had not received prior radiation were offered the FTBI-based regimen. Two patients who received the chemotherapy-based regimen received involved field radiation after ASCT. PBSCs were thawed and reinfused on day 0. Only one patient did not receive the entire collection, as he had extremely high cell doses. A back-up product of 12 x 106 CD34+ cells/kg was reserved. G-CSF 5 ug/kg was started on day +1. Antibacterial prophylaxis was with levofloxacin 500 mg daily, and antifungal prophylaxis consisted of either fluconazole 400 mg/day or amphotericin. 0.1 to 0.15 mg/kg/day, and antiviral prophylaxis was with acyclovir 5 mg/kg twice daily until day +25. All patients were maintained on their HAART regimen.
RESULTS
Between March 1998 and August 2003, 20 patients with HIV-associated lymphomas were enrolled. Median age at ASCT was 44 years (range, 11-68 years). Most had relapsed disease or failed to achieve a CR with front-line therapy: 7 in first relapse, 2 in second relapse, 5 in first PR. Four patients with a high-risk IPI score were in first CR and one in second and third CR, respectively. The histologic subtypes and chemotherapy regimens are listed in Table 1. Patients received a median of 2 chemotherapy regimens prior to ASCT (range, 1-4 regimens). The median CD4 count at lymphoma diagnosis was 174 cells/mcl (range, 30-500 cells/mcl), and median viral load at lymphoma diagnosis was 26 120 cp/mL (range, 500-1 300 000 cp/mL). At study entry 17 patients had undetectable viral loads, and the remaining 3 had a viral load ranging between 700 and 6500 cp/mL. The median CD4 count at study entry was 175 cells/mcl (range, 25-1064 cells/mcl). Fifteen patients were on a protease inhibitor--based regimen and the remainder on a non-nucleoside reverse transcriptase inhibitor--based regimen. One patient had concomitant hepatitis B infection. His liver biopsy prior to ASCT showed no evidence of cirrhosis.
A median of 10.6 x 106 CD34+ cells/kg were collected after a median of 4 days of apheresis. One patient required prolonged apheresis (10 days). No significant toxicity in terms of rise in HIV viral load or opportunistic infections was seen during apheresis.
Seventeen patients received the chemotherapy-based conditioning regimen, and 3 received the radiation-based regimen. Antiretroviral therapy was given to all patients from the start of conditioning onward, but only 9 patients were able to tolerate it throughout. The remainder were intolerant due to gastrointestinal toxicity such as nausea in the majority or mucositis in the FTBI patients. The same HAART regimen was restarted in all but 2 patients after a median of 21 days. One patient did not resume his antiretroviral therapy, as he developed multiorgan failure. Another patient was changed from the 2 nucleoside reverse transcriptase inhibitors (NRTI) zidovudine and lamivudine and one non-nucleoside reverse transcriptase inhibitor (NNRTI) nevirapine to abacavir, lamivudine, and efavirenz. Most patients were able to resume HAART by 2 months after ASCT with the exception of one, who had persistent nausea and noncompliance that was in part ascribed to depression. Genotyping was not performed prior to the resumption of HAART. All patients engrafted at a median of 11 days for neutrophil engraftment (range, 9-23 days). The markedly delayed engraftment of 23 days was in the one patient who was on zidovudine as part of his HAART regimen.
Other treatment-related toxicities included liver function abnormalities in most patients: grade 1 to 2 in 16, and grade 3 to 4 in 3. One of these patients, the oldest in the series, age 68, ultimately developed cardiomyopathy and renal failure and died at day +22 after ASCT. The other recovered uneventfully, and the third had late hepatoxicity over 10 months after ASCT that responded to a change in his antiretroviral regimen. Two patients developed an engraftment syndrome manifested as high temperatures, hypotension, skin rash, and fluid retention. Both responded to corticosteroids. Interstitial pneumonitis that was ascribed to the carmustine developed in one patient and was successfully treated with corticosteroids. Pericarditis presumed to be secondary to cyclophosphamide was seen in one patient and was treated with nonsteroidals and a 5-day course of low-dose prednisone. This same patient also developed transient atrial fibrillation that was treated with medical therapy. Another patient with a history of supraventricular (SVT) arrhythmias prior to the transplant developed recurrent SVT and had to be cardioverted. The patient who had delayed engraftment after ASCT developed subdural hematomas during a period of thrombocytopenia after a lumbar puncture. They ultimately required surgical drainage. The patient also developed hemorrhagic cystitis that responded to bladder irrigation.
Early infectious complications prior to engraftment included gram-positive bacteremias in 4 patients and fever and neutropenia in 8 patients. One patient had vancomycin-resistant enterococcus isolated from a bronchoalveolar lavage. Postengraftment, opportunistic infections were more common. Two patients who were not compliant with prophylaxis developed pneumocystis pneumonia. One of these patients also developed pulmonary aspergillus after steroid treatment for his pneumocystis. One patient never had documented pneumocystis but was treated empirically for this after a chest x-ray demonstrated interstitial infiltrates. Two patients developed disseminated herpes zoster. Cytomegalovirus (CMV) retinitis developed in one patient, and 2 had asymptomatic viremia. All patients responded to therapy. At one year after ASCT, one patient acquired hepatitis C, which was found upon evaluation of liver function abnormalities.
The underlying HIV infection did not worsen as a result of the transplant. While CD4 counts nadired at approximately 6 months after transplant, they recovered to pretransplant levels by one year in all patients (Figure 1). The median CD4 count at one year was 187 cells/mcl and 472 cells/mcl at 2 years. The HIV viral load tended to fluctuate, in part due to prolonged noncompliance with HAART in one patient. Most (76%) had undetectable viral loads at one year (range, 0-500 000 cp/mL); 2 of the 4 with detectable viral loads at one year were undetectable at study enrollment. However, one of these patients did not resume HAART until one year after ASCT. Of the 17 long-term survivors, 10 required changes in their antiretroviral regimen during the observation period, due to viral failure.
Median length of follow-up is 31.8 months (range, 5.5-70). Of the 20 patients, 17 are alive and in remission. One patient with a follow-up of 5.5 months had a positive positron emission tomography (PET) scan at his 100-day restaging, but no CAT scan correlation. Two patients died of relapsed lymphoma early after transplant (2 months, 4 months, respectively). One patient died of regimen-related toxicity at day +22. The progression-free survival (PFS) is 85% (95% CI 69-100), and overall survival is 85% for the entire group (Figure 2). For the patients who received transplants beyond first CR, the overall survival (OS) is 81% (95% CI 62-100) (Figure 3) and PFS is 81% (69-100).
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