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ION-1 NAIVES & ION-2 Treatment-Exp SVR Rates - RBV Cirrhotics/Ethnicity/ baseline NS5A resistance
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In ION-1 there appears no affect of with or without Rbv or 12 vs 24 weeks. But look below to ION-2 for differences.
ION-2 TREAT-Exp
Certain patient subgroups show a lower SVR rate without Rbv & with 12 weeks. Gt1b 2/23 87% had SVR without Rbv vs 23/23 100% with Rbv for 12 wks, but SVR rate was 100% with 24 weeks. Patients with cirrhosis had 85% w/o Rbv & 81% with Rbv with 12 weeks vs 100% (22/22 & 22/22, respectively) with 24 weeks. Ethnicity- blacks & latinos did the same with/without Rbv 12 or 24 weeks. Patients with prior therapy had better SVR rates with 24 weeks, particularly those with cirrhosis & prior experience.
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