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The effect of physical activity on cardiometabolic health and inflammation in treated HIV infection
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"HIV+ adults who engage in 2.5 hours of moderate intensity exercise per week are likely to experience lower levels of inflammation & subclinical vascular disease.....and reduced pericardial fat [see discussion below"
Sahera Dirajlal-Fargo, Allison R Webel, Chris T Longenecker, Bruce Kinley, Danielle Labbato, Abdus Sattar, Grace A McComsey
Antiviral Therapy Oct 12 2015
Abstract
Background: In HIV-uninfected populations, physical activity decreases mortality and inflammation. Inflammation is a potential cause for co-morbidities in HIV+ adults, the evidence examining the effect of physical activity on cardiometabolic health is limited. This analysis examines the relationship between physical activity, cardiometabolic health and inflammation.
Methods: We conducted a nested study within the SATURN-HIV trial in which 147 HIV+ adults were randomized to 10 mg daily rosuvastatin or placebo. Measures of physical activity, cardiometabolic health, inflammation, and vascular disease (carotid artery intima media thickness and Computed Tomography-acquired measures pericardial fat volume) were assessed at baseline and through 96 weeks. Spearman correlations and multivariable analyses were used to explore relationships between physical activity, cardiometabolic health and inflammation.
Results: Median age (Q1, Q3) was 46 (40.4, 52.7) years, 80% were male, 69% were African American and 46% on protease inhibitors. Baseline median physical activity was 44 minutes per week (0, 150), 24% of participants performed greater than 150 minutes per week. At baseline, physical activity correlated with several markers of cardiometabolic health and inflammation (all pē0.05). Over all time points median physical activity was independently associated with carotid distensibility (ß = 2.53, p = 0.008), pericardial fat volume (ß = -6.13, p = 0.001) and IL 6 (ß = -0.468, p < 0.001).
Conclusions: Physical activity is associated with vascular disease, endothelial function, and may be an adjuvant to decreasing co-morbidities in HIV+ adults. Further studies should examine long-term effects of physical activity on cardiometabolic health and inflammation in this population.
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