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Failure to Test and Identify Perinatally
Infected Children Born to Hepatitis C-Positive Women
 
 
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Safety and Efficacy of Ledipasvir/Sofosbuvir Fixed Dose Combination +/-Ribavirin in Adolescents and Children With Chronic HCV-Infection...... https://clinicaltrials.gov/ct2/show/NCT02249182.....sites listed A Study to Evaluate Treatment of Hepatitis C Virus Infection in Pediatric Subjects (ZIRCON) Abbvie study, 3-17 yrs old, site listed
 
......https://clinicaltrials.gov/ct2/show/NCT02486406?term=ombitasvir/paritaprevir/ritonavir+&+dasabuvir+pediatric&rank=1......The purpose of this three part study is to evaluate the pharmacokinetics (Part 1), safety/efficacy (Part 2), and long-term follow-up (Part 3) of ombitasvir (OBV), paritaprevir (PTV), ritonavir (RTV) with or without dasabuvir (DSV) and with or without ribavirin (RBV) in pediatric subjects with genotype 1 or 4 chronic hepatitis C virus (HCV) infection.
 
"Education about the importance of HCV-related medical care for mother and child must be effectively communicated to women at all points of care ......This study showed that a notable number of births are occurring to HCV-positive women but that a gap exists in testing of perinatally-exposed children. As a part of standard healthcare, women should be encouraged to communicate their HCV infection statuses to relevant providers....In addition, healthcare providers of mother and child must communicate with each other and adequately test every child who is exposed to HCV. Identifying children with perinatal HCV infection and introducing them to specialty care and eventual treatment and cure is imperative to their comprehensive wellbeing.
 
Of the births to mothers known to be HCV-positive, 20.3% (n=109) had received an HCV test during their pregnancy......84% (N=181 per year), are not being adequately tested for HCV infection......it is likely that there are many more HCV-infected mothers in Philadelphia who have not yet been identified.....4.6% (N=500) of women in the Hepatitis Registry gave birth to 537 children during the study period.....Using the 5% vertical transmission rate, an estimated 27 children of the 537 births to HCV-positive mothers are expected to be chronically infected with HCV......38 (45%) were adequately tested and four (5%) were identified as Confirmed Perinatal cases (all HCV-Ab and HCV RNA positive).....HCV-positive mothers in this study show evidence of being socioeconomically disadvantaged: more likely unmarried, less educated, and publicly insured than mothers without a reported HCV positive result. Infected mothers were also nearly eight times as likely to be white, an observation that correlates with the nationwide increase in HCV infection among young non-Hispanic white injection drug users.[4] Barriers to HCV-specific care within this population have been well identified and include a lack of knowledge about the severity of the infection, inadequate insurance coverage, limited access to HCV care, and ineligibility for treatment
 
This study demonstrates that a notable number of HCV-positive women are giving birth in a major US city, and the majority of their children, 84% (N=181 per year), are not being adequately tested for HCV infection. As a result, most chronically infected children are unidentified and therefore unable to be linked to specialty care. These findings support the 2012 analysis that highlighted a nationwide failure to identify HCV Ab-positive children.[27] The delay in identifying pediatric HCV infections can elevate a child's risk of developing adverse health consequences of prolonged infection, increase secondary transmission, and result in higher health care costs.[7, 23]
 
Of the births to mothers known to be HCV-positive, 20.3% (n=109) had received an HCV test during their pregnancy, though testing in pregnancy had no effect on the likelihood of their child being tested for HCV (data not shown).....8,119 females (12-54 years) were HCV-positive and in the Hepatitis Registry. Of these, 500 (5%) had delivered ≥1 child, accounting for 537 (1%) of the 55,623 children born in Philadelphia during the study period. Eighty-four (16%) of these children had HCV testing.....The final match indicated that 4.6% (N=500) of women in the Hepatitis Registry gave birth to 537 children during the study period (Table 1, Figure 1), 57% of whom had no known HCV RNA result......At the time of this analysis, PDPH had received an HCV test result for 84 children (16%) who were born to HCV-positive women in the Registry (Figure 1, Table 1, Figure 2). Of these, 38 (45%) were adequately tested and four (5%) were identified as Confirmed Perinatal cases (all HCV-Ab and HCV RNA positive) (Figure 2).
 
Using the 5% vertical transmission rate, an estimated 27 children of the 537 births to HCV-positive mothers are expected to be chronically infected with HCV (Figure 1). Given that four (15%) are Confirmed Perinatal children, 23 (85%) children remain unidentified and may be living with chronic HCV infection (Figure 1). The lower limit for the estimate of children perinatally infected with HCV is 22 (4%), which would leave 18 (82%) of children unidentified.
 
Children who test positive for HCV RNA should be evaluated by a pediatric HCV specialist and considered for treatment
 
Prenatal screening for HCV is not routine, in part because there are no proven clinical interventions that prevent or minimize vertical transmission, including elective caesarian section and treatments which are not approved for use during pregnancy (ribavirin is contraindicated and direct acting antivirals (DAA's) are not approved).[1, 11, 14, 15] While the American Congress of Obstetricians and Gynecologists (ACOG) recommends HCV screening for pregnant women who have risk factors such as a history of injection drug use (IDU) and/or HIV infection, many patients remain unidentified using risk-based testing criteria.[3, 16] Failure to capture all HCV-infected pregnant women through risk-based screening has driven other countries, including Australia in 2013, to adopt universal prenatal HCV screening.[17, 18]
 
Since pediatric cases of disease are often asymptomatic, all children born to HCV-infected women should be tested to rule out vertical transmission.[19] Current guidelines from the American Association for the Study of Liver Disease (AASLD) and the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN) recommend that children born to HCV-infected women be tested for anti-HCV antibody (HCV-Ab) after 18 months of age; screening before this age is less reliable due to the possible presence of maternal antibodies. Any positive HCV-Ab result should be followed by a HCV ribonucleic acid (RNA) testto confirm that the child is infected.[19, 20] HCV RNA tests may also be performed after two months of age, with retesting after an additional two months, or performed one-time after 12 months of age.[21] Multiple tests may be needed because viral titers can fluctuate in the first year of life, though testing for HCV RNA earlier may assuage parental anxiety.[20]
 
A 2012 analysis of National Health and Nutrition Examination Survey (NHANES) data found that only 4.9% of expected perinatally HCV infected children were identified in the United States (U.S.), and medical record review of the pediatric HCV cases in Florida revealed that less than 2% of known cases had received follow-up care.[27] Given the uncertain generalizability of NHANES estimates when used to approximate populations at high risk for HCV, the 2012 study likely underestimates the true burden of perinatal HCV infections. [1-3, 27] This study uses population-based surveillance data to estimate both the scale of perinatal exposures and the success of current testing recommendations for children born to HCV-positive women."
 
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Failure to Test and Identify Perinatally Infected Children Born to Hepatitis C-Positive Women
 
Clin Infect Dis. January 20, 2016
 
Danica E. Kuncio, E. Claire Newbern, Caroline C. Johnson, Kendra M. Viner Division of Disease Control, Philadelphia Department of Public Health, Philadelphia, USA
 
Abstract
 
Background.
Vertical transmission of hepatitis C virus (HCV) is the most common route of pediatric HCV infection. Approximately 5% percent of children born to HCV-positive mothers develop chronic infection. Recommendations employ risk-based HCV testing of pregnant women, and screening children at a young age. This study assesses testing rates of children born to HCV-positive mothers in a major US city with a high burden of HCV infection.
 
Methods. HCV surveillance data reported to the Philadelphia Department of Public Health (PDPH) are housed in the Hepatitis Registry. Additional tests, including negative results, were retrospectively collected. HCV data were matched with 2011-2013 birth certificates of children ≥20 months to identify HCV-positive mothers and screened children. The observed perinatal HCV seropositivity rate was compared to the expected rate (5%).
 
Results. 8,119 females (12-54 years) were HCV-positive and in the Hepatitis Registry. Of these, 500 (5%) had delivered ≥1 child, accounting for 537 (1%) of the 55,623 children born in Philadelphia during the study period. Eighty-four (16%) of these children had HCV testing; four (1% of the total) were Confirmed cases. Twenty-four additional children are expected to have chronic HCV infection, but were not identified by 20 months of age.
 
Conclusion. These findings illustrate that a significant number of women giving birth in Philadelphia are HCV-positive and that most of their at-risk children remain untested. To successfully identify all HCV-infected children and integrate them into HCV-specific care, practices for HCV screening of pregnant women and their children should be improved.
 
Background
 
Vertical transmission (mother to infant) is the primary route of hepatitis C virus (HCV) infection in children. An estimated 40,000 children are born annually to HCV-positive women, resulting in up to 4,000 new perinatally infected children each year. [1-3] As the HCV infection rate among young people continues to increase as a result of the rise in injection drug use (IDU), a concomitant increase in the number perinatally infected children may be expected.[2, 4, 5] Pediatric HCV can impact cognitive development and the overall health of children, and may lead to more severe adverse outcomes including cirrhosis, hepatocellular carcinoma, and liver failure.[6-9]
 
The mechanism and risk-factors of vertical transmission are poorly understood, however extended exposure to maternal blood, elevated HCV viremia during pregnancy, and coinfection with human immunodeficiency virus (HIV) are shown to increase the risk of transmission.[10-14] While some infants spontaneously clear HCV infection before 18 months of age, the proportion of children who develop chronic infection after vertical transmission from HCV-positive/HIV-negative mothers is thought to be approximately 5%, though study results range from 1 – 11%.[10, 12-14]
 
Prenatal screening for HCV is not routine, in part because there are no proven clinical interventions that prevent or minimize vertical transmission, including elective caesarian section and treatments which are not approved for use during pregnancy (ribavirin is contraindicated and direct acting antivirals (DAA's) are not approved).[1, 11, 14, 15] While the American Congress of Obstetricians and Gynecologists (ACOG) recommends HCV screening for pregnant women who have risk factors such as a history of injection drug use (IDU) and/or HIV infection, many patients remain unidentified using risk-based testing criteria.[3, 16] Failure to capture all HCV-infected pregnant women through risk-based screening has driven other countries, including Australia in 2013, to adopt universal prenatal HCV screening.[17, 18]
 
Since pediatric cases of disease are often asymptomatic, all children born to HCV-infected women should be tested to rule out vertical transmission.[19] Current guidelines from the American Association for the Study of Liver Disease (AASLD) and the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN) recommend that children born to HCV-infected women be tested for anti-HCV antibody (HCV-Ab) after 18 months of age; screening before this age is less reliable due to the possible presence of maternal antibodies. Any positive HCV-Ab result should be followed by a HCV ribonucleic acid (RNA) testto confirm that the child is infected.[19, 20] HCV RNA tests may also be performed after two months of age, with retesting after an additional two months, or performed one-time after 12 months of age.[21] Multiple tests may be needed because viral titers can fluctuate in the first year of life, though testing for HCV RNA earlier may assuage parental anxiety.[20]
 
Children who test positive for HCV RNA should be evaluated by a pediatric HCV specialist and considered for treatment (interferon-a and ribavirin are currently approved for children three years of age and older).[20] Treating HCV infection during childhood can prevent liver damage caused by long-term chronic HCV infection, has the advantage of improved adherence with parental supervision, and can limit secondary transmission that may occur as a result of risk behaviors initiated during adolescence. However, adverse consequences of the current pediatric treatment regimen should be considered and may lead physicians to warehouse patients for improved regimens in the pipeline. [7, 20, 22, 23] While DAA's have not yet been approved for use in children, they are more tolerable and more effective in curing HCV infection in adults and will likely become available for children within a few years.[22]
 
The public health impact of perinatal HCV infection remains largely unexplored. In both Australia and Europe, studies have been conducted to assess effects of HCV in pregnant women, policies on perinatal HCV screening, and vertical transmission risks.[1, 14, 24-26] A 2012 analysis of National Health and Nutrition Examination Survey (NHANES) data found that only 4.9% of expected perinatally HCV infected children were identified in the United States (U.S.), and medical record review of the pediatric HCV cases in Florida revealed that less than 2% of known cases had received follow-up care.[27] Given the uncertain generalizability of NHANES estimates when used to approximate populations at high risk for HCV, the 2012 study likely underestimates the true burden of perinatal HCV infections. [1-3, 27] This study uses population-based surveillance data to estimate both the scale of perinatal exposures and the success of current testing recommendations for children born to HCV-positive women.
 
Results
 
From January 1st, 2011- July 1st, 2013, Philadelphia residents gave birth to 55,623 children (Figure 1). The maternal age at birth ranged from 13 - 54 years (Table 1). The Hepatitis Registry contained 8,119 women in the same age range with a positive HCV infection status (Figure 1). Date of first laboratory report for these women ranged from 1998 to the study period. The original match between these data sources yielded 568 children born to HCV-positive women, of whom 5.5% (N=31) had died or moved at the time of analysis, and were subsequently excluded (Figure 1). The final match indicated that 4.6% (N=500) of women in the Hepatitis Registry gave birth to 537 children during the study period (Table 1, Figure 1), 57% of whom had no known HCV RNA result.
 
Births during the study period to women who were not HCV-positive were significantly different than the 1% (537/55,623) of births to mothers who were HCV-positive. In both univariate and multivariate models, births to HCV-positive mothers had higher adjusted odds of being to white, older, less educated, publically insured, and unmarried women than to mothers without a positive HCV test result (Table 1). Retention of multiple births (sequential or non-singleton) by mothers did not significantly change the results of these analyses (data not shown). Of the births to mothers known to be HCV-positive, 20.3% (n=109) had received an HCV test during their pregnancy, though testing in pregnancy had no effect on the likelihood of their child being tested for HCV (data not shown).
 
At the time of this analysis, PDPH had received an HCV test result for 84 children (16%) who were born to HCV-positive women in the Registry (Figure 1, Table 1, Figure 2). Of these, 38 (45%) were adequately tested and four (5%) were identified as Confirmed Perinatal cases (all HCV-Ab and HCV RNA positive) (Figure 2). An additional four children were identified as Probable Perinatal cases (all tested HCV-Ab positive before six months of age with no follow-up testing) that will require further testing to confirm infection. Two of the Confirmed Perinatal children were born to women with no reported RNA result, three were born to mothers who were not tested for HCV during pregnancy, and one to a woman who was reported for the first time after childbirth (data not shown). There were 34 adequately tested children classified as Uninfected, including four with HCV-Ab positive and HCV RNA-negative test results after 18 months of age who are thought to have spontaneously cleared the infection.
 
Using the 5% vertical transmission rate, an estimated 27 children of the 537 births to HCV-positive mothers are expected to be chronically infected with HCV (Figure 1). Given that four (15%) are Confirmed Perinatal children, 23 (85%) children remain unidentified and may be living with chronic HCV infection (Figure 1). The lower limit for the estimate of children perinatally infected with HCV is 22 (4%), which would leave 18 (82%) of children unidentified.
 
Discussion
 
This study demonstrates that a notable number of HCV-positive women are giving birth in a major US city, and the majority of their children, 84% (N=181 per year), are not being adequately tested for HCV infection. As a result, most chronically infected children are unidentified and therefore unable to be linked to specialty care. These findings support the 2012 analysis that highlighted a nationwide failure to identify HCV Ab-positive children.[27] The delay in identifying pediatric HCV infections can elevate a child's risk of developing adverse health consequences of prolonged infection, increase secondary transmission, and result in higher health care costs.[7, 23]
 
HCV-positive mothers in this study show evidence of being socioeconomically disadvantaged: more likely unmarried, less educated, and publicly insured than mothers without a reported HCV positive result. Infected mothers were also nearly eight times as likely to be white, an observation that correlates with the nationwide increase in HCV infection among young non-Hispanic white injection drug users.[4] Barriers to HCV-specific care within this population have been well identified and include a lack of knowledge about the severity of the infection, inadequate insurance coverage, limited access to HCV care, and ineligibility for treatment.[28, 29] As a result of these barriers and the limits of risk-based testing, it is likely that there are many more HCV-infected mothers in Philadelphia who have not yet been identified.[16, 30] While there are currently no interventions that can prevent a woman with HCV from perinatally transmitting to her children, screening pregnant women for HCV infection is critical to ensuring that exposed children are tested for HCV infection. Prenatal care also provides an opportunity to identify HCV infected women not regularly engaged in the healthcare system.
 
There are multiple explanations for the considerable gap in the testing of children born to HCV-positive women. First, screening of pregnant women for HCV is not routine in prenatal care and HCV-related risk factors may not be regularly ascertained; thus opportunities for an active dialogue between infected mothers and their healthcare providers are missed. Indeed, there is a need for increased physician education about HCV infection in general, including prevention, early detection, and current therapies.[30, 31] Secondly, women may be unaware of the severity and transmissibility of their HCV infection and therefore not disclose their status to their obstetrician. Education about the importance of HCV-related medical care for mother and child must be effectively communicated to women at all points of care. Third, pediatricians may not be alerted to a mother's HCV infection status from the obstetrician, birthing hospital, or mother, therefore preventing adequate testing from being initiated.[19, 20] Further, pediatricians may be waiting until a later age to test children for HCV, however children in this study born in 2011 were tested at statistically the same rate as those born in 2013 (data not shown). Lastly, many pediatricians may be unaware or skeptical of the guidelines for testing children exposed to HCV. This study showed that even when performed, testing often did not adhere to current guidelines.. Wide-spread education of pediatricians on the adequate testing recommendations and a review of the national guidelines may be warranted. Without improved communication between primary care providers, obstetricians, pediatricians, and HCV-infected mothers, children are likely to remain tested.
 
This study has a few limitations. Surveillance-based research relies on the reporting of laboratory test results. While additional data were obtained to more accurately assess HCV testing among both mothers and children, it is likely that some missing data still exists.
 
Another limitation is the absence of maternal HIV status in this study. Since HCV-HIV co-infection increases the risk of perinatal transmission, our analysis likely underestimates the number of children perinatally infected with HCV during the study period. It is also likely that there are women infected with HCV who were unreported to PDPH or who remain untested as evidenced by children identified in this study with no PDPH record of maternal infection (data not shown). Inclusion of these women would further increase the number of potential children with perinatal HCV infection. Given the wide range of published perinatal transmission rates resulting from differences in study design and populations,[10] it is possible that the true expected number of HCV-infected children may differ from study estimates. Finally, the up to 30% of HCV-positive mothers with unknown RNA status may include some women who would have tested HCV RNA-negative. Inclusion of HCV Ab-positive mothers with unknown RNA status was important because many high-risk groups may only be tested in environments where HCV RNA testing is not offered, such as methadone clinics and drug rehabilitation facilities. Two of the Confirmed Perinatal cases were born to women with unknown RNA status and the perinatal transmission estimate adjusted for HCV RNA-negative mothers was still noteworthy.
 
It is important for both patients and providers to be aware of the risks of vertical HCV transmission, and to understand the steps required to identify children perinatally infected with HCV. This study showed that a notable number of births are occurring to HCV-positive women but that a gap exists in testing of perinatally-exposed children. As a part of standard healthcare, women should be encouraged to communicate their HCV infection statuses to relevant providers. In addition, healthcare providers of mother and child must communicate with each other and adequately test every child who is exposed to HCV. Identifying children with perinatal HCV infection and introducing them to specialty care and eventual treatment and cure is imperative to their comprehensive wellbeing. Further efforts should ascertain the reasons for the gap in testing of children born to women with HCV infection and guide future research and policy discussions surrounding the care of HCV-infected women and their children.

 
 
 
 
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