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INSHU: Drug use and reinfection during and following Hepatitis C Virus treatment with Elbasvir/Grazoprevir among patients receiving Opiate Agonist Therapy: C-EDGE Co-STAR study
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Reported by Jules Levin
7th International Symposium on Hepatitis Care in Substance Users
Cascais, Portugal
19 - 21 September 2018
Gregory Dore1, Jason Grebely1, Frederick Altice2, Alain H. Litwin3, Olav Dalgard4, Edward J. Gane5, Oren Shibolet6, Brian Conway7, Ronald Nahass8, Anne Luetkemeyer9, Cheng-Yuan Peng10, David Iser11, Isaias N. Gendrano12, Michelle M. Kelly12, Hsueh-Cheng Huang12, Peggy Hwang12, Eliav Barr12, Michael Robertson12, Heather Platt12
1Kirby Institute, UNSW Sydney, Sydney, NSW, Australia; 2Yale University, New Haven, CT, USA; 3Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, USA; 4Institute of Clinical Medicine, Akershus University, Oslo, Norway;
5Auckland City Hospital, Auckland, New Zealand; 6Liver Unit, Department of Gastroenterology, Tel Aviv Medical Center, Tel Aviv, Israel; 7Vancouver Infectious Diseases Centre, Vancouver, BC, Canada; 8ID Care, Hillsborough, NJ, USA; 9University of California, San Francisco, San Francisco, CA, USA; 10China Medical University Hospital, Taichung, Taiwan; 11St. Vincent's University Hospital, Melbourne, VIC, Australia; 12Merck & Co., Inc., Kenilworth, NJ, USA
NOTE regarding discordancy between reported drug use at 6 months and 1 month prior:
We have discussed this particular issue when we first started looking at the interim results from the ABQ. We noticed there was discordance between the 6M and 1M data. We discussed analyzing the results from the survey 2 ways. The first way would be to analyze all the data as reported by the subject. The second way would be to apply logic to the instances where the same question is asked at different time points. The logic would be exactly as you describe, however, we would have to make an assumption that the vale at 1 month is true and then impute the positive value back to the 6 month time point, and not assume the 6 month value is correct and impute forward to the 1 month time point. We realize that this is a bit complicated and could not perform this on interim data. We will plan to do this one the data is final.
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