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Immunologic Predictors of Bone Loss in a Contemporary HIV Cohort
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Reported by Jules Levin
CROI 2015
Feb 23-26, Seattle, WA
Edgar T. Overton1, Katherine Huppler Hullsiek2, Gerome Escota3, Ken Lichtenstein4, Lois Conley5, Pragna Patel5, John T. Brooks5, Irini Sereti6, and Jason V. Baker7,8, for the CDC SUN (Study to Understand the Natural History of HIV/AIDS in the Era of Effective Therapy) Investigators 1-University of Alabama School of Medicine, Birmingham, AL; 2-Division of Biostatistics, University of Minnesota, Minneapolis, MN; 3-Washington University School of Medicine, St. Louis, MO; 4-National Jewish Health, Denver, CO; 5-Division of HIV/AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, GA; 6-National Institute of Allergy and Infectious Disease (NIAID), NIH, Bethesda, MD; 7-Department of Medicine, University of Minnesota, Minneapolis, MN; 8-Division of Infectious Diseases, Hennepin County Medical Center, Minneapolis, MN
from Program Abstract: HIV is a recognized risk factor for osteoporosis. The role of soluble markers and cellular immune parameters on HIV-related bone loss remains unclear.. We evaluated inflammatory markers and total hip bone mineral density (BMD) changes in a prospective HIV cohort enrolled during 2004-2006 (SUN Study)....74% undetectable viral load......Conclusions: In this healthy HIV adult cohort with predominantly controlled viremia, total hip BMD decline was associated with IL-6, replicative senescent T-cells, CCR5+ and tissue factor expressing monocytes. Memory CD4+ and CD8+ CD28+ T cells were associated with increases in BMD. Immunologic alterations that persist after virologic suppression may contribute to ongoing loss of BMD.
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