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Geriatric Syndromes are Common Among Older HIV-Infected Adults
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Reported by Jules Levin
CROI 2014
Meredith Greene MD1, Victor Valcour1, Yinghui Miao1,2, Ken Covinsky1,2, Joy Madamba1, Monica Mattes3, Harry Lampiris1,2, Jeffrey Martin1, Steven Deeks1 1University of California, San Francisco, 2San Francisco VA Medical Center, San Francisco, CA,3University of Central Florida College of Medicine
more than half of participants had 2 or more geriatric syndromes, which was associated with CD4 nadir
Geriatric syndromes such as falls, frailty, and functional impairment are multifactorial conditions used to identify vulnerable older adults
Cross-sectional study within UCSF SCOPE cohort
study subjects: Age 50 and older (54-62), on ART with an undetectable viral load for ≥3 years
We measured frequencies of four geriatric syndromes-
- Geriatric syndromes: Falls: Self-report "Have you fallen in the past year?"
- Urinary incontinence: Self-report based on the International Consultation on Incontinence Questionnaire (ICIQ)
- Pre-frailty and frailty using Fried Frailty Criteria
- Functional Impairment: Self-report of Activities of Daily Living (ADLs) and Instrumental Activities of Daily Living (IADLs)
RESULTS
from program abstract:
The median CD4 count was 577 (IQR 393-715), median CD4 nadir was 172 (IQR 50-318), and median length of HIV infection was 22 years (IQR 18-25). 49% had been exposed to zidovudine, stavudine or didanosine. Subjects had a median of 4 (IQR 3-6) co-morbidities and were taking a median of 9 (IQR 5-12) non-antiretroviral medications. 86% of subjects had at least one geriatric syndrome and 54% had 2 or more syndromes. 38 subjects (27%) reported at least one fall, 36 (25%) reported urinary incontinence, and 64 (45%) reported difficulty with at least 1 instrumental activity of daily living. 12 (9%) subjects met the full criteria for frailty, while 79 (56%) met criteria for pre-frailty. Every 50 unit increase in CD4 nadir (RR 0.93, 95% CI 0.88-0.99) and being employed (RR 0.57, 95% CI 0.37-0.89) were associated with a lower relative risk of the composite outcome of 2 or more geriatric syndromes
Geriatric Syndromes are Common Among Older HIV-Infected Adults
Reported by Jules Levin
CROI 2014
Meredith Greene MD1, Victor Valcour1, Yinghui Miao1,2, Ken Covinsky1,2, Joy Madamba1, Monica Mattes3, Harry Lampiris1,2, Jeffrey Martin1, Steven Deeks1 1University of California, San Francisco, 2San Francisco VA Medical Center, San Francisco, CA,3University of Central Florida College of Medicine
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