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Premature Aging and Immune Senescence in HIV-1-Infected Children
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Reported by Jules Levin
CROI 2015 Feb 23-26, Seattle, WA
Ketty Gianesin1, Antoni Noguera-Julian2, Marisa Zanchetta3, Osvalda Rampon4, Claudia Fortuny2, Mireia Camos5, Carlo Giaquinto4, Anita De Rossi1
1 Section of Oncology and Immunology, Unit of Viral Oncology and AIDS Reference Center, Department of Surgery, Oncology and Gastroenterology-DiSCOG, University of Padova, Padova, Italy
2 Unitat d'Infectologia, Servei de Pediatria; Hospital Sant Joan de Deu-Universitat de Barcelona, Barcelona, Spain
3 Istituto Oncologico Veneto (IOV)-IRCCS, Padova, Italy
4 Department of Mother and Child Health, University of Padova, Padova, Italy
5 Servei d'Hematologia; Hospital Sant Joan de Deu-Universitat de Barcelona, Barcelona, Spain
.....this report follows comments immediately below......"The proportion of CD8+ cells with a senescent phenotype (CD28-CD57+) was higher in HIV+ children.......HIV-1-infected children had a lower telomere length compared to age- and gender- matched controls, suggesting an accelerated biological aging; - age-adjusted telomere length is shorter in ART-untreated than in ART-treated children, thus suggesting that HIV-1 itself, rather than exposure to antiretroviral drugs, influences the senescence process"
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from Jules: At this CROI 2015 as there has been for many recent years were numerous reports on aging, comorbidities and inflammation: reports in adults that frailty occurs more often & sooner in HIV+, that immune senescence sets in more quickly in HIV+ and that HIV appears to cause this & accelerated onset for geriatric conditions, frailty & aging-related comorbidities, and that inflammation & immune activation are associated with these clinical developments for patients. And several studies at CROI 2015 finding similarly to numerous other recent studies including in the HHS Guidelines that early ART is the best way to try to stem these clinical concerns, studies find early ART has a benefit to preventing or improving these problems. Peter HUNT MD from UCSF delivered a plenary lecture at CROI 2015 reviewing this subject......http://www.croiwebcasts.org/console/player/25505?mediaType=slideVideo&......of note numerous studies have provided data that early ART decreases inflammation & immune activation.....
CROI: ART soon after infection linked to better CD4 recovery through 10 years - (03/09/15)
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Premature Aging and Immune Senescence in HIV-1-Infected Children
Reported by Jules Levin
CROI 2015 Feb 23-26, Seattle, WA
Ketty Gianesin1, Antoni Noguera-Julian2, Marisa Zanchetta3, Osvalda Rampon4, Claudia Fortuny2, Mireia Camos5, Carlo Giaquinto4, Anita De Rossi1
1 Section of Oncology and Immunology, Unit of Viral Oncology and AIDS Reference Center, Department of Surgery, Oncology and Gastroenterology-DiSCOG, University of Padova, Padova, Italy
2 Unitat d'Infectologia, Servei de Pediatria; Hospital Sant Joan de Deu-Universitat de Barcelona, Barcelona, Spain
3 Istituto Oncologico Veneto (IOV)-IRCCS, Padova, Italy
4 Department of Mother and Child Health, University of Padova, Padova, Italy
5 Servei d'Hematologia; Hospital Sant Joan de Deu-Universitat de Barcelona, Barcelona, Spain
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