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IL-6 Partially Mediates the Effect of HIV Status on Survival....Inflammation & HIV Associated with Mortality in HIV+ Vets...HIV+ with >500 viral load have 33-100% greater mortality in VA Cohort
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Reported by Jules Levin
CROI 2015 Feb 23-26, Seattle, WA
......"IL-6, sCD14, D-dimer (inflammation) are associated with mortality independently of HIV status"....from Jules: inflammation is lower when viral load is <500 and inflammation generally increases when viral load increases independently of HIV status"....interestingly the HIV+ were compared to HIV in the VA, average age was 52-59, and the VA HIV- subjects were rather sickly as sickly as the VA HIV+ subjects: mortality was the same for HIV- & HIV+ with <500 viral load but with viral load 500-1000 mortality was 33% greater in HIV+ compared to HIV- and when viral load was >1000 mortality was double for HIV+ vs HIV- vets
Kaku So-Armah1, Matthew Freiberg10, Amy Justice2, David Rimland3, Maria Rodriguez-Barradas4, Adeel Butt5, David Leaf6, Russell Tracy7, Mohammad Sajadi8, Cynthia Gibert9
1 Yale University School of Medicine, New Haven, Connecticut, United States;2 VA Connecticut Healthcare System, West Haven, Connecticut, United States;3 Veterans Affairs Medical Center, Atlanta, Georgia, United States;4 Veterans Affairs Medical Center, Houston, Texas, United States;5 Sheikh Khalifa Medical City, Abu Dhabi, United Arab Emirates;6 Veterans Affairs Medical Center, Greater Los Angeles, California, United States;7 University of Vermont, Burlington, Vermont, United States;8 Veterans Affairs Medical Center, Baltimore, Maryland, United States;9 Veterans Affairs Medical Center, Washington, District of Columbia, United States;10 Vanderbilt University School of Medicine, Nashville, Tennessee, United States
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