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Predictors and Outcomes of Incident High Cholesterol in Adults on ART in South Africa. Total Cholesterol Associated with Decreased Kidney Function
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Reported by Jules Levin
CROI 2015 Feb 23-26, Seattle, WA
Denise Evans1, Alana T Brennan1,2, Faith Moyo1, David Spencer3, Kay Mahomed3, Mhairi Maskew2, Lawrence Long2, Sydney B Rosen1,2, Matthew P Fox1,2,4 1Health Economics and Epidemiology Research Office, Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa, 2Center for Global Health & Development, Boston University, USA, 3Right to Care, Johannesburg, South Africa, 4Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA
From Jules- this study outcome suggests a statin can help to prevent kidney disease as this study found an association between total cholesterol & decreased kidney function (eGFR <90): "23% had an elevated cholesterol ³6mg/dl after starting ART....12% of those with an elevated TC developed moderate or severe renal insufficiency (CrCl <90ml/min) .....Those with persistently high TC (³6mg/dl) had a higher rate of renal insufficiency (20.9/100 pys) after high TC vs. those who reduced their TC < (18.8/100 pys)."
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