 |
|
|
| |
Frailty and Cause-Specific Hospitalization
among Aging HIV-Infected and Uninfected Persons
|
| |
| |
"We have previously identified a significant relationship of frailty with both HIV and increased mortality risk among PWID.....[now we report] Frailty is significantly associated with all-cause, chronic disease and infectious disease hospitalization risk"
Frailty and Cause-Specific Hospitalization among Aging HIV-Infected and Uninfected Persons......."Frailty is a key aging-related syndrome of vulnerability found to be associated with increased morbidity and mortality among older HIV-uninfected adults. We have previously identified a significant relationship of frailty with both HIV and increased mortality risk among PWID. In this study, we sought to determine the relationship of frailty to risk for specific classes of hospitalization events in this population......Frailty was ascertained in the ALIVE cohort of persons with prior or current injection drug use based on the 5 Fried phenotype criteria. Hospitalization events were ascertained from 2005-2012 .....frailty was significantly associated with increased AIDS hospitalization risk (aHR 6.30) ......Frailty was also independently associated with non-AIDS infectious disease hospitalization risk (aHR 2.21) .......The frailty phenotype selectively predicts vulnerability to chronic disease and infectious disease related hospitalization, independent of comorbidity, degree of HIV immunosuppression and virologic control. Frail persons are susceptible to increased hospitalization for both AIDS and Non-AIDS infection."
Reported by Jules Levin
CROI 2015 Feb 23-26, Seattle, WA
Damani A. Piggott1, Abimereki D. Muzaale1, Shruti H. Mehta1, Ryan P. Westergaard2, Todd T. Brown1, Kushang V. Patel3, Sean X. Leng1, Gregory D. Kirk1
1Johns Hopkins University, Baltimore, MD, USA; 2University of Wisconsin, Madison, WI, USA; 3University of Washington, Seattle, WA, USA
|
| |
|
|
|
|
|
