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LONGITUDINAL VIRAL TRAJECTORY AMONG WOMEN IN THE WOMEN'S INTERAGENCY HIV STUDY
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from Jules: it looks like 20% are on HAART, 39% on ART & 30.47% of women on HAART & 38% on ART are reported here to have undetectable viral load
Reported by Jules Levin
CROI 2017 Feb 14-16 Seattle, WA
Seble G Kassaye1, Cuiwei Wang1, Jeff Collmann2, Tracey Wilson3, Kathryn Anastos4, Mardge Cohen5, Ruth M Greenblatt6, Joel Milam7, Stephen Gange8, and Michael Plankey1
1Georgetown University Medical Center, Washington, DC, USA. 2The Office of the Senior Vice President for Research, Georgetown University, Washington DC, USA;3 State University of New York, Downstate Medical Center, Brooklyn, NY, USA, 4 Albert Einstein College of Medicine and Montefiore Health Systems, New York, NY, United States, 5 Stroger Hospital, Cook County Bureau of Health Services, Chicago, IL, USA; 6UCSF Schools of Pharmacy and Medicine, San Francisco, CA, USA, 7
Keck School of Medicine, University of Southern California, CA, USA; 8Johns Hopkins University, Baltimore, MD, USA
The same group reported:
CROI: Longitudinal HIV Viral Trajectories and Co-Morbidities Longitudinal in the WIHS: Viral Suppression Key to Survival - (02/16/17)
from Jules: in Figure 1 you see only 29% were non-viremic, 29% with intermittent viremia and 41% with sustained viremia ...."Long term viral suppression key to survival, but risk factors for cardiovascular disease greater on HAART"
"On multivariate analysis, individuals with AIDS defining conditions and AIDS-associated cancers were more likely to have sustained viremia .....Compared to women with sustained viremia, women with viral suppression were more likely (HR 1.4, p=0.0072) to report risk factors for cardiovascular disease (hypertension, hyperlipidemia, diabetes), without concurrent increased risk of cardiovascular disease outcomes" from Jules: perhaps long term viral suppression reduces inflammation but risk factors like lipids etc may be greater on HAART.
CROI: Viral Load Dynamics Among Persons with Diagnosed HIV: United States, 2014 - (02/16/17) CDC - "the continuum of care outcome measure, which relies on single viral load measures, overestimates viral suppression by 20%....longitudinal measures better inform viral burden & treatment & care efforts....about half with diagnosed HIV in the US in 2014 had durable viral suppression"
WEBCAST: http://www.croiwebcasts.org/console/player/33365?mediaType=slideVideo&
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